Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides

Oligonucleotides composed of 2′-O-methyl and locked nucleic acid residues complementary to HIV-1 trans-activation responsive element TAR block Tat-dependent trans-activation in a HeLa cell assay when delivered by cationic lipids. We describe an improved procedure for synthesis and purification under...

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Detalles Bibliográficos
Autores principales: Turner, John J., Arzumanov, Andrey A., Gait, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546131/
https://www.ncbi.nlm.nih.gov/pubmed/15640444
http://dx.doi.org/10.1093/nar/gki142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546131/
https://www.ncbi.nlm.nih.gov/pubmed/15640444
http://dx.doi.org/10.1093/nar/gki142

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