Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides

Phosphorothioate-modified antisense oligodeoxynucleotides (ASOs) are used to suppress gene expression by inducing RNase H-mediated cleavage with subsequent degradation of the target mRNA. However, previous observations suggest that ASO/RNase H can also result in the generation of stable mRNA cleavag...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasselblatt, Peter, Hockenjos, Birgit, Thoma, Christian, Blum, Hubert E., Offensperger, Wolf-Bernhard
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546143/
https://www.ncbi.nlm.nih.gov/pubmed/15640448
http://dx.doi.org/10.1093/nar/gki155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546143/
https://www.ncbi.nlm.nih.gov/pubmed/15640448
http://dx.doi.org/10.1093/nar/gki155

Ejemplares similares