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Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides

Phosphorothioate-modified antisense oligodeoxynucleotides (ASOs) are used to suppress gene expression by inducing RNase H-mediated cleavage with subsequent degradation of the target mRNA. However, previous observations suggest that ASO/RNase H can also result in the generation of stable mRNA cleavag...

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Detalles Bibliográficos
Autores principales:	Hasselblatt, Peter, Hockenjos, Birgit, Thoma, Christian, Blum, Hubert E., Offensperger, Wolf-Bernhard
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546143/ https://www.ncbi.nlm.nih.gov/pubmed/15640448 http://dx.doi.org/10.1093/nar/gki155

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