Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease

BACKGROUND: The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer’s disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after adjusting for...

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Detalles Bibliográficos
Autores principales: Nho, Kwangsik, Kim, Sungeun, Horgusluoglu, Emrin, Risacher, Shannon L., Shen, Li, Kim, Dokyoon, Lee, Seunggeun, Foroud, Tatiana, Shaw, Leslie M., Trojanowski, John Q., Aisen, Paul S., Petersen, Ronald C., Jack, Clifford R., Weiner, Michael W., Green, Robert C., Toga, Arthur W., Saykin, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461522/
https://www.ncbi.nlm.nih.gov/pubmed/28589856
http://dx.doi.org/10.1186/s12920-017-0267-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461522/
https://www.ncbi.nlm.nih.gov/pubmed/28589856
http://dx.doi.org/10.1186/s12920-017-0267-0

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