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Taking promoters out of enhancers in sequence based predictions of tissue-specific mammalian enhancers

BACKGROUND: Many genetic diseases are caused by mutations in non-coding regions of the genome. These mutations are frequently found in enhancer sequences, causing disruption to the regulatory program of the cell. Enhancers are short regulatory sequences in the non-coding part of the genome that are...

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Detalles Bibliográficos
Autores principales: Herman-Izycka, Julia, Wlasnowolski, Michal, Wilczynski, Bartek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461523/
https://www.ncbi.nlm.nih.gov/pubmed/28589862
http://dx.doi.org/10.1186/s12920-017-0264-3