The accumulation of MMS-induced single strand breaks in G(1) phase is recombinogenic in DNA polymerase β defective mammalian cells

DNA polymerase (Pol) β null mouse embryonic fibroblasts provide a useful cell system to investigate the effects of alterations in base excision repair (BER) on genome stability. These cells are characterized by hypersensitivity to the cytotoxic effects of methyl methanesulfonate (MMS) and by decreas...

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Detalles Bibliográficos
Autores principales: Pascucci, Barbara, Russo, Maria Teresa, Crescenzi, Marco, Bignami, Margherita, Dogliotti, Eugenia
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546155/
https://www.ncbi.nlm.nih.gov/pubmed/15647510
http://dx.doi.org/10.1093/nar/gki168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546155/
https://www.ncbi.nlm.nih.gov/pubmed/15647510
http://dx.doi.org/10.1093/nar/gki168

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