Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability

PARN, a poly(A)-specific ribonuclease, binds the 5′ cap-structure of mRNA and initiates deadenylation-dependent decay. Eukaryotic initiation factor 4E (eIF4E) also binds to the cap structure, an interaction that is critical for initiating cap-dependent translation. The stability of various mRNA tran...

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Detalles Bibliográficos
Autores principales: Seal, Ruth, Temperley, Richard, Wilusz, Jeffrey, Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M. A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546156/
https://www.ncbi.nlm.nih.gov/pubmed/15653638
http://dx.doi.org/10.1093/nar/gki169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546156/
https://www.ncbi.nlm.nih.gov/pubmed/15653638
http://dx.doi.org/10.1093/nar/gki169

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