APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability

XRCC1 protein is essential for mammalian viability and is required for the efficient repair of single strand breaks (SSBs) and damaged bases in DNA. XRCC1-deficient cells are genetically unstable and sensitive to DNA damaging agents. XRCC1 has no known enzymatic activity and is thought to act as a s...

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Detalles Bibliográficos
Autores principales: Sossou, Marguerite, Flohr-Beckhaus, Claudia, Schulz, Ina, Daboussi, Fayza, Epe, Bernd, Radicella, J. Pablo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546158/
https://www.ncbi.nlm.nih.gov/pubmed/15647512
http://dx.doi.org/10.1093/nar/gki173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546158/
https://www.ncbi.nlm.nih.gov/pubmed/15647512
http://dx.doi.org/10.1093/nar/gki173

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