Cargando…
APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability
XRCC1 protein is essential for mammalian viability and is required for the efficient repair of single strand breaks (SSBs) and damaged bases in DNA. XRCC1-deficient cells are genetically unstable and sensitive to DNA damaging agents. XRCC1 has no known enzymatic activity and is thought to act as a s...
Autores principales: | Sossou, Marguerite, Flohr-Beckhaus, Claudia, Schulz, Ina, Daboussi, Fayza, Epe, Bernd, Radicella, J. Pablo |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546158/ https://www.ncbi.nlm.nih.gov/pubmed/15647512 http://dx.doi.org/10.1093/nar/gki173 |
Ejemplares similares
-
Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair
por: Campalans, Anna, et al.
Publicado: (2013) -
APE1 senses DNA single-strand breaks for repair and signaling
por: Lin, Yunfeng, et al.
Publicado: (2020) -
Processing oxidatively damaged bases at DNA strand breaks by APE1
por: Whitaker, Amy M, et al.
Publicado: (2022) -
XRCC1 is required for DNA single-strand break repair in human cells
por: Brem, Reto, et al.
Publicado: (2005) -
DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4
por: Lees-Miller, Susan P.
Publicado: (2014)