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Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferase
DNA methylation plays important roles via regulation of numerous cellular mechanisms in diverse organisms, including humans. The paradigm bacterial methyltransferase (MTase) HhaI (M.HhaI) catalyzes the transfer of a methyl group from the cofactor S-adenosyl-l-methionine (AdoMet) onto the target cyto...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546160/ https://www.ncbi.nlm.nih.gov/pubmed/15653631 http://dx.doi.org/10.1093/nar/gki175 |