The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells

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Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to the ordered firing of origins during S phase. Here, we show that the level of histone H4 acetylation correlates with the frequency of replication initiation as measured by...

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Detalles Bibliográficos
Autores principales: Kemp, Michael G., Ghosh, Maloy, Liu, Guoqi, Leffak, Michael
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546162/
https://www.ncbi.nlm.nih.gov/pubmed/15653633
http://dx.doi.org/10.1093/nar/gki177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546162/
https://www.ncbi.nlm.nih.gov/pubmed/15653633
http://dx.doi.org/10.1093/nar/gki177

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