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The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells
Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to the ordered firing of origins during S phase. Here, we show that the level of histone H4 acetylation correlates with the frequency of replication initiation as measured by...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546162/ https://www.ncbi.nlm.nih.gov/pubmed/15653633 http://dx.doi.org/10.1093/nar/gki177 |