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Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

BACKGROUND: The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not fully understood. Giant, hypernucleated, inactive osteoclasts were found in MRO...

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Detalles Bibliográficos
Autores principales: Gross, Christian, Weber, Manuel, Creutzburg, Kay, Möbius, Patrick, Preidl, Raimund, Amann, Kerstin, Wehrhan, Falk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461625/
https://www.ncbi.nlm.nih.gov/pubmed/28587628
http://dx.doi.org/10.1186/s12967-017-1230-8