Characterizing QT interval prolongation in early clinical development: a case study with methadone

Recently, we have shown how pharmacokinetic–pharmacodynamic (PKPD) modeling can be used to assess the probability of QT interval prolongation both in dogs and humans. A correlation between species has been identified for a drug‐specific parameter, making it possible to prospectively evaluate nonclin...

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Detalles Bibliográficos
Autores principales: Dubois, Vincent F. S., Danhof, Meindert, Della Pasqua, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461648/
https://www.ncbi.nlm.nih.gov/pubmed/28596836
http://dx.doi.org/10.1002/prp2.284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461648/
https://www.ncbi.nlm.nih.gov/pubmed/28596836
http://dx.doi.org/10.1002/prp2.284

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