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Characterizing QT interval prolongation in early clinical development: a case study with methadone
Recently, we have shown how pharmacokinetic–pharmacodynamic (PKPD) modeling can be used to assess the probability of QT interval prolongation both in dogs and humans. A correlation between species has been identified for a drug‐specific parameter, making it possible to prospectively evaluate nonclin...
Autores principales: | Dubois, Vincent F. S., Danhof, Meindert, Della Pasqua, Oscar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461648/ https://www.ncbi.nlm.nih.gov/pubmed/28596836 http://dx.doi.org/10.1002/prp2.284 |
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