A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

BACKGROUND: β-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s disease (AD) development, and Aβ monomers have normal physiological function. The antibodies or vaccines against Aβ monomers have serious problems, such as side effects and low curative effects. Therefore, it...

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Detalles Bibliográficos
Autores principales: Wang, Shao-wei, Liu, Dong-qun, Zhang, Ling-xiao, Ji, Mei, Zhang, Yang-xin, Dong, Quan-xiu, Liu, Shu-ying, Xie, Xi-xiu, Liu, Rui-tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461751/
https://www.ncbi.nlm.nih.gov/pubmed/28592267
http://dx.doi.org/10.1186/s13195-017-0267-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461751/
https://www.ncbi.nlm.nih.gov/pubmed/28592267
http://dx.doi.org/10.1186/s13195-017-0267-5

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