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Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix

In this issue of Clinical Science, Krishna and colleagues describe recent work on thrombospondin-1 (TSP-1) maturation and its association with slower growth of aortic aneurysm in TSP-1 knockdown mouse models. The authors conclude that TSP-1 deficiency promotes maladaptive remodeling of the extracell...

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Detalles Bibliográficos
Autores principales: Satoh, Mamoru, Nasu, Takahito, Osaki, Takuya, Hitomi, Sho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461940/
https://www.ncbi.nlm.nih.gov/pubmed/28592701
http://dx.doi.org/10.1042/CS20170275