Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix

In this issue of Clinical Science, Krishna and colleagues describe recent work on thrombospondin-1 (TSP-1) maturation and its association with slower growth of aortic aneurysm in TSP-1 knockdown mouse models. The authors conclude that TSP-1 deficiency promotes maladaptive remodeling of the extracell...

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Autores principales: Satoh, Mamoru, Nasu, Takahito, Osaki, Takuya, Hitomi, Sho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461940/
https://www.ncbi.nlm.nih.gov/pubmed/28592701
http://dx.doi.org/10.1042/CS20170275
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author Satoh, Mamoru
Nasu, Takahito
Osaki, Takuya
Hitomi, Sho
author_facet Satoh, Mamoru
Nasu, Takahito
Osaki, Takuya
Hitomi, Sho
author_sort Satoh, Mamoru
collection PubMed
description In this issue of Clinical Science, Krishna and colleagues describe recent work on thrombospondin-1 (TSP-1) maturation and its association with slower growth of aortic aneurysm in TSP-1 knockdown mouse models. The authors conclude that TSP-1 deficiency promotes maladaptive remodeling of the extracellular matrix (ECM) leading to accelerated aortic aneurysm progression. We comment on a causal relation between TSP-1 and the progression of aortic aneurysm.
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spelling pubmed-54619402017-06-13 Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix Satoh, Mamoru Nasu, Takahito Osaki, Takuya Hitomi, Sho Clin Sci (Lond) Commentaries In this issue of Clinical Science, Krishna and colleagues describe recent work on thrombospondin-1 (TSP-1) maturation and its association with slower growth of aortic aneurysm in TSP-1 knockdown mouse models. The authors conclude that TSP-1 deficiency promotes maladaptive remodeling of the extracellular matrix (ECM) leading to accelerated aortic aneurysm progression. We comment on a causal relation between TSP-1 and the progression of aortic aneurysm. Portland Press Ltd. 2017-06-07 /pmc/articles/PMC5461940/ /pubmed/28592701 http://dx.doi.org/10.1042/CS20170275 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentaries
Satoh, Mamoru
Nasu, Takahito
Osaki, Takuya
Hitomi, Sho
Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title_full Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title_fullStr Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title_full_unstemmed Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title_short Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
title_sort thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461940/
https://www.ncbi.nlm.nih.gov/pubmed/28592701
http://dx.doi.org/10.1042/CS20170275
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