A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease d...

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Detalles Bibliográficos
Autores principales: Brecher, Matthew, Li, Zhong, Liu, Binbin, Zhang, Jing, Koetzner, Cheri A., Alifarag, Adham, Jones, Susan A., Lin, Qishan, Kramer, Laura D., Li, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462475/
https://www.ncbi.nlm.nih.gov/pubmed/28542603
http://dx.doi.org/10.1371/journal.ppat.1006411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462475/
https://www.ncbi.nlm.nih.gov/pubmed/28542603
http://dx.doi.org/10.1371/journal.ppat.1006411

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