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Uncovering direct and indirect molecular determinants of chromatin loops using a computational integrative approach
Chromosomal organization in 3D plays a central role in regulating cell-type specific transcriptional and DNA replication timing programs. Yet it remains unclear to what extent the resulting long-range contacts depend on specific molecular drivers. Here we propose a model that comprehensively assesse...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462476/ https://www.ncbi.nlm.nih.gov/pubmed/28542178 http://dx.doi.org/10.1371/journal.pcbi.1005538 |