Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters

[Image: see text] The combination of methotrexate with epidermal growth factor receptor (EGFR) recombinant antibody, cetuximab, is currently being investigated in treatment of head and neck carcinoma. As methotrexate is cleared by renal excretion, we studied the effect of cetuximab on renal methotre...

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Detalles Bibliográficos
Autores principales: Caetano-Pinto, Pedro, Jamalpoor, Amer, Ham, Janneke, Goumenou, Anastasia, Mommersteeg, Monique, Pijnenburg, Dirk, Ruijtenbeek, Rob, Sanchez-Romero, Natalia, van Zelst, Bertrand, Heil, Sandra G., Jansen, Jitske, Wilmer, Martijn J., van Herpen, Carla M. L., Masereeuw, Rosalinde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462489/
https://www.ncbi.nlm.nih.gov/pubmed/28493713
http://dx.doi.org/10.1021/acs.molpharmaceut.7b00308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462489/
https://www.ncbi.nlm.nih.gov/pubmed/28493713
http://dx.doi.org/10.1021/acs.molpharmaceut.7b00308

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