Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR

A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modes...

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Detalles Bibliográficos
Autores principales: Villar, Victor H., Nguyen, Tra Ly, Terés, Silvia, Bodineau, Clément, Durán, Raúl V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462510/
https://www.ncbi.nlm.nih.gov/pubmed/28616576
http://dx.doi.org/10.1080/23723556.2017.1297284
Descripción
Sumario:A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.

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