Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR

A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modes...

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Detalles Bibliográficos
Autores principales: Villar, Victor H., Nguyen, Tra Ly, Terés, Silvia, Bodineau, Clément, Durán, Raúl V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462510/
https://www.ncbi.nlm.nih.gov/pubmed/28616576
http://dx.doi.org/10.1080/23723556.2017.1297284
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author Villar, Victor H.
Nguyen, Tra Ly
Terés, Silvia
Bodineau, Clément
Durán, Raúl V.
author_facet Villar, Victor H.
Nguyen, Tra Ly
Terés, Silvia
Bodineau, Clément
Durán, Raúl V.
author_sort Villar, Victor H.
collection PubMed
description A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.
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spelling pubmed-54625102018-03-03 Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR Villar, Victor H. Nguyen, Tra Ly Terés, Silvia Bodineau, Clément Durán, Raúl V. Mol Cell Oncol Author's View A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic. Taylor & Francis 2017-03-03 /pmc/articles/PMC5462510/ /pubmed/28616576 http://dx.doi.org/10.1080/23723556.2017.1297284 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Villar, Victor H.
Nguyen, Tra Ly
Terés, Silvia
Bodineau, Clément
Durán, Raúl V.
Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title_full Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title_fullStr Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title_full_unstemmed Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title_short Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
title_sort escaping mtor inhibition for cancer therapy: tumor suppressor functions of mtor
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462510/
https://www.ncbi.nlm.nih.gov/pubmed/28616576
http://dx.doi.org/10.1080/23723556.2017.1297284
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