The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals,...

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Detalles Bibliográficos
Autores principales: Erstad, Derek J., Tager, Andrew M., Hoshida, Yujin, Fuchs, Bryan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462520/
https://www.ncbi.nlm.nih.gov/pubmed/28616586
http://dx.doi.org/10.1080/23723556.2017.1311827
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author Erstad, Derek J.
Tager, Andrew M.
Hoshida, Yujin
Fuchs, Bryan C.
author_facet Erstad, Derek J.
Tager, Andrew M.
Hoshida, Yujin
Fuchs, Bryan C.
author_sort Erstad, Derek J.
collection PubMed
description Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
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spelling pubmed-54625202018-03-31 The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer Erstad, Derek J. Tager, Andrew M. Hoshida, Yujin Fuchs, Bryan C. Mol Cell Oncol Author's View Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC. Taylor & Francis 2017-03-31 /pmc/articles/PMC5462520/ /pubmed/28616586 http://dx.doi.org/10.1080/23723556.2017.1311827 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Erstad, Derek J.
Tager, Andrew M.
Hoshida, Yujin
Fuchs, Bryan C.
The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title_full The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title_fullStr The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title_full_unstemmed The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title_short The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
title_sort autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462520/
https://www.ncbi.nlm.nih.gov/pubmed/28616586
http://dx.doi.org/10.1080/23723556.2017.1311827
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