Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransd...

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Detalles Bibliográficos
Autores principales: Erickson, Timothy, Morgan, Clive P, Olt, Jennifer, Hardy, Katherine, Busch-Nentwich, Elisabeth, Maeda, Reo, Clemens, Rachel, Krey, Jocelyn F, Nechiporuk, Alex, Barr-Gillespie, Peter G, Marcotti, Walter, Nicolson, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462536/
https://www.ncbi.nlm.nih.gov/pubmed/28534737
http://dx.doi.org/10.7554/eLife.28474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462536/
https://www.ncbi.nlm.nih.gov/pubmed/28534737
http://dx.doi.org/10.7554/eLife.28474

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