Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment. Using freeze fracture electron microscopy, we show here that the yeast NPC orthologs, Ncr1p and Npc2p, are essential f...

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Detalles Bibliográficos
Autores principales: Tsuji, Takuma, Fujimoto, Megumi, Tatematsu, Tsuyako, Cheng, Jinglei, Orii, Minami, Takatori, Sho, Fujimoto, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462540/
https://www.ncbi.nlm.nih.gov/pubmed/28590904
http://dx.doi.org/10.7554/eLife.25960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462540/
https://www.ncbi.nlm.nih.gov/pubmed/28590904
http://dx.doi.org/10.7554/eLife.25960

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