Activity-independent targeting of mTOR to lysosomes in primary osteoclasts

Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mTORC1 is located on lysosomes and has been reported to disas...

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Detalles Bibliográficos
Autores principales: Wang, Andrew, Carraro-Lacroix, Luciene R., Owen, Celeste, Gao, Bowen, Corey, Paul N., Tyrrell, Pascal, Brumell, John H., Voronov, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462732/
https://www.ncbi.nlm.nih.gov/pubmed/28592812
http://dx.doi.org/10.1038/s41598-017-03494-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462732/
https://www.ncbi.nlm.nih.gov/pubmed/28592812
http://dx.doi.org/10.1038/s41598-017-03494-2

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