Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)

Sphingomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect that could exacerbate disease in CF and COPD patients. The mechanism by which sphingomyelin catalysis inhibits CFTR is not known but evidence suggests that it occurs independently of CFTR’s regulat...

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Detalles Bibliográficos
Autores principales: Stauffer, B. B., Cui, G., Cottrill, K. A., Infield, D. T., McCarty, N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462758/
https://www.ncbi.nlm.nih.gov/pubmed/28592822
http://dx.doi.org/10.1038/s41598-017-03103-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462758/
https://www.ncbi.nlm.nih.gov/pubmed/28592822
http://dx.doi.org/10.1038/s41598-017-03103-2

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