A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle

The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules. This is a key step in the control of viral infections through CD8+ T-cells. The herpes simplex virus type-1 encodes an 88 amino a...

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Detalles Bibliográficos
Autores principales: Matschulla, Tony, Berry, Richard, Gerke, Carolin, Döring, Marius, Busch, Julia, Paijo, Jennifer, Kalinke, Ulrich, Momburg, Frank, Hengel, Hartmut, Halenius, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462769/
https://www.ncbi.nlm.nih.gov/pubmed/28592828
http://dx.doi.org/10.1038/s41598-017-02994-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462769/
https://www.ncbi.nlm.nih.gov/pubmed/28592828
http://dx.doi.org/10.1038/s41598-017-02994-5

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