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A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules. This is a key step in the control of viral infections through CD8+ T-cells. The herpes simplex virus type-1 encodes an 88 amino a...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462769/ https://www.ncbi.nlm.nih.gov/pubmed/28592828 http://dx.doi.org/10.1038/s41598-017-02994-5 |