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Cdc6 contributes to abrogating the G1 checkpoint under hypoxic conditions in HPV E7 expressing cells

The human papillomavirus (HPV) plays a central role in cervical carcinogenesis and its oncogene E7 is essential in this process. We showed here that E7 abrogated the G1 cell cycle checkpoint under hypoxia and analyzed key cell cycle related proteins for their potential role in this process. To furth...

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Detalles Bibliográficos
Autores principales: Chen, Hanxiang, Zhang, Qishu, Qiao, Lijun, Fan, Xueli, Zhang, Weifang, Zhao, Weiming, Chen, Jason J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462782/
https://www.ncbi.nlm.nih.gov/pubmed/28592805
http://dx.doi.org/10.1038/s41598-017-03060-w