ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Here we demonstrate that ML290 is a biased agonist in human cells expressing RXFP1 with long-t...

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Detalles Bibliográficos
Autores principales: Kocan, Martina, Sarwar, Mohsin, Ang, Sheng Y., Xiao, Jingbo, Marugan, Juan J., Hossain, Mohammed A., Wang, Chao, Hutchinson, Dana S., Samuel, Chrishan S., Agoulnik, Alexander I., Bathgate, Ross A. D., Summers, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462828/
https://www.ncbi.nlm.nih.gov/pubmed/28592882
http://dx.doi.org/10.1038/s41598-017-02916-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462828/
https://www.ncbi.nlm.nih.gov/pubmed/28592882
http://dx.doi.org/10.1038/s41598-017-02916-5

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