Targeting genomic rearrangements in tumor cells using Cas9-mediated insertion of a suicide gene

Specifically targeting genomic rearrangements and mutations in tumor cells has remained an elusive goal in cancer therapy. Here, we use Cas9-based genome editing to introduce the gene for the pro-drug converting enzyme ‘herpes simplex virus type 1 thymidine kinase’ (HSV1-tk) into the genome of cance...

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Detalles Bibliográficos
Autores principales: Chen, Zhang-Hui, Yu, Yan P., Zuo, Ze-Hua, Nelson, Joel B., Michalopoulos, George K., Monga, Satdatshan, Liu, Silvia, Tseng, George, Luo, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462845/
https://www.ncbi.nlm.nih.gov/pubmed/28459452
http://dx.doi.org/10.1038/nbt.3843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462845/
https://www.ncbi.nlm.nih.gov/pubmed/28459452
http://dx.doi.org/10.1038/nbt.3843

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