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γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

GABA-A receptors (GABA(A)Rs) are pentameric ligand-gated ion channels that are assembled mainly from α (α1–6), β (β1–3) and γ (γ1–3) subunits. Although GABA(A)Rs containing γ2L subunits mediate most of the inhibitory neurotransmission in the brain, significant expression of γ1 subunits is seen in th...

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Detalles Bibliográficos
Autores principales: Dixon, Christine L., Sah, Pankaj, Keramidas, Angelo, Lynch, Joseph W., Durisic, Nela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462899/
https://www.ncbi.nlm.nih.gov/pubmed/28642681
http://dx.doi.org/10.3389/fnmol.2017.00178