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Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming Ca(V)1.3 Ca(2+) Channel Subunit and Promote Its Membrane Expression

Rab interacting molecules (RIMs) are multi-domain proteins that positively regulate the number of Ca(2+) channels at the presynaptic active zone (AZ). Several molecular mechanisms have been demonstrated for RIM-binding to components of the presynaptic Ca(2+) channel complex, the key signaling elemen...

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Detalles Bibliográficos
Autores principales: Picher, Maria M., Oprişoreanu, Ana-Maria, Jung, SangYong, Michel, Katrin, Schoch, Susanne, Moser, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462952/
https://www.ncbi.nlm.nih.gov/pubmed/28642685
http://dx.doi.org/10.3389/fncel.2017.00160