Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons

Gastrointestinal dysfunction is a common side-effect of chemotherapy leading to dose reductions and treatment delays. These side-effects may persist up to 10 years post-treatment. A topoisomerase I inhibitor, irinotecan (IRI), commonly used for the treatment of colorectal cancer, is associated with...

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Detalles Bibliográficos
Autores principales: McQuade, Rachel M., Stojanovska, Vanesa, Donald, Elizabeth L., Rahman, Ahmed A., Campelj, Dean G., Abalo, Raquel, Rybalka, Emma, Bornstein, Joel C., Nurgali, Kulmira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462962/
https://www.ncbi.nlm.nih.gov/pubmed/28642718
http://dx.doi.org/10.3389/fphys.2017.00391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462962/
https://www.ncbi.nlm.nih.gov/pubmed/28642718
http://dx.doi.org/10.3389/fphys.2017.00391

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