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Estimation of insulin secretion, glucose uptake by tissues, and liver handling of glucose using a mathematical model of glucose-insulin homeostasis in lean and obese mice

Destruction of the insulin-producing β-cells is the key determinant of diabetes mellitus regardless of their types. Due to their anatomical location within the islets of Langerhans scattered throughout the pancreas, it is difficult to monitor β-cell function and mass clinically. To this end, we prop...

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Detalles Bibliográficos
Autores principales: Brenner, Michael, Abadi, Sakineh Esmaeili Mohsen, Balouchzadeh, Ramin, Lee, H. Felix, Ko, Hoo Sang, Johns, Michael, Malik, Nehal, Lee, Joshua J., Kwon, Guim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463011/
https://www.ncbi.nlm.nih.gov/pubmed/28626803
http://dx.doi.org/10.1016/j.heliyon.2017.e00310