Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma

Catechol‐O‐methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O‐methylation. Tolcapone, a drug commonly used in the treatment of Parkinson's disease, is a potent inhibitor of COMT and previous studies indicate that Tolcapone increases the bioavailability...

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Detalles Bibliográficos
Autores principales: Maser, Tyler, Rich, Maria, Hayes, David, Zhao, Ping, Nagulapally, Abhinav B., Bond, Jeffrey, Saulnier Sholler, Giselle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463066/
https://www.ncbi.nlm.nih.gov/pubmed/28429453
http://dx.doi.org/10.1002/cam4.1065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463066/
https://www.ncbi.nlm.nih.gov/pubmed/28429453
http://dx.doi.org/10.1002/cam4.1065

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