Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

Parkinson’s disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron content. α-...

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Detalles Bibliográficos
Autores principales: Duce, James A., Wong, Bruce X., Durham, Hannah, Devedjian, Jean-Christophe, Smith, David P., Devos, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463308/
https://www.ncbi.nlm.nih.gov/pubmed/28592304
http://dx.doi.org/10.1186/s13024-017-0186-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463308/
https://www.ncbi.nlm.nih.gov/pubmed/28592304
http://dx.doi.org/10.1186/s13024-017-0186-8

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