Simulating therapeutic drug monitoring results for dose individualisation to maintain investigator blinding in a randomised controlled trial

BACKGROUND: Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve a plasma drug concentration within a narrow target range above the efficacy concentration but below the toxicity concentration. However, TDM with dose individuali...

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Detalles Bibliográficos
Autores principales: Lesosky, Maia, Joska, John, Decloedt, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463313/
https://www.ncbi.nlm.nih.gov/pubmed/28592271
http://dx.doi.org/10.1186/s13063-017-1992-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463313/
https://www.ncbi.nlm.nih.gov/pubmed/28592271
http://dx.doi.org/10.1186/s13063-017-1992-6

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