Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Goncalves, Victor, Brannigan, James A., Laporte, Alice, Bell, Andrew S., Roberts, Shirley M., Wilkinson, Anthony J., Leatherbarrow, Robin J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463734/
https://www.ncbi.nlm.nih.gov/pubmed/28626547
http://dx.doi.org/10.1039/c6md00531d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463734/
https://www.ncbi.nlm.nih.gov/pubmed/28626547
http://dx.doi.org/10.1039/c6md00531d

Ejemplares similares