Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas

BACKGROUND. The evolution of primary glioblastoma (GBM) is poorly understood. Multifocal GBM (ie, multiple synchronous lesions in one patient) could elucidate GBM development. METHODS. We present the first comprehensive study of 12 GBM foci from 6 patients using array-CGH, spectral karyotyping, gene...

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Detalles Bibliográficos
Autores principales: Abou-El-Ardat, Khalil, Seifert, Michael, Becker, Kerstin, Eisenreich, Sophie, Lehmann, Matthias, Hackmann, Karl, Rump, Andreas, Meijer, Gerrit, Carvalho, Beatriz, Temme, Achim, Schackert, Gabriele, Schröck, Evelin, Krex, Dietmar, Klink, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464316/
https://www.ncbi.nlm.nih.gov/pubmed/28201779
http://dx.doi.org/10.1093/neuonc/now231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464316/
https://www.ncbi.nlm.nih.gov/pubmed/28201779
http://dx.doi.org/10.1093/neuonc/now231

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