The binding orientations of structurally-related ligands can differ; A cautionary note

Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5-HT(3) and α7 nACh receptors and its binding orientation has...

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Detalles Bibliográficos
Autores principales: Ruepp, Marc-David, Wei, Hao, Leuenberger, Michele, Lochner, Martin, Thompson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464333/
https://www.ncbi.nlm.nih.gov/pubmed/28137449
http://dx.doi.org/10.1016/j.neuropharm.2017.01.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464333/
https://www.ncbi.nlm.nih.gov/pubmed/28137449
http://dx.doi.org/10.1016/j.neuropharm.2017.01.023

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