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The binding orientations of structurally-related ligands can differ; A cautionary note
Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5-HT(3) and α7 nACh receptors and its binding orientation has...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464333/ https://www.ncbi.nlm.nih.gov/pubmed/28137449 http://dx.doi.org/10.1016/j.neuropharm.2017.01.023 |