Folding correction of ABC‐transporter ABCB1 by pharmacological chaperones: a mechanistic concept

Point mutations of ATP‐binding cassette (ABC) proteins are a common cause of human diseases. Available crystal structures indicate a similarity in the architecture of several members of this protein family. Their molecular architecture makes these proteins vulnerable to mutation, when critical struc...

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Detalles Bibliográficos
Autores principales: Spork, Matthias, Sohail, Muhammad Imran, Schmid, Diethart, Ecker, Gerhard F., Freissmuth, Michael, Chiba, Peter, Stockner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464349/
https://www.ncbi.nlm.nih.gov/pubmed/28603639
http://dx.doi.org/10.1002/prp2.325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464349/
https://www.ncbi.nlm.nih.gov/pubmed/28603639
http://dx.doi.org/10.1002/prp2.325

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