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Folding correction of ABC‐transporter ABCB1 by pharmacological chaperones: a mechanistic concept
Point mutations of ATP‐binding cassette (ABC) proteins are a common cause of human diseases. Available crystal structures indicate a similarity in the architecture of several members of this protein family. Their molecular architecture makes these proteins vulnerable to mutation, when critical struc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464349/ https://www.ncbi.nlm.nih.gov/pubmed/28603639 http://dx.doi.org/10.1002/prp2.325 |