Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to anti-malarial agent dihydroartemisinin

The oxidative pentose phosphate pathway (PPP) is crucial for cancer cell metabolism and tumor growth. We recently reported that targeting a key oxidative PPP enzyme, 6-phosphogluconate dehydrogenase (6PGD), using our novel small molecule 6PGD inhibitors Physcion and its derivative S3, shows anti-can...

Descripción completa

Detalles Bibliográficos
Autores principales: Elf, Shannon, Lin, Ruiting, Xia, Siyuan, Pan, Yaozhu, Shan, Changliang, Wu, Shaoxiong, Lonial, Sagar, Gaddh, Manila, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., Fan, Jun, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464402/
https://www.ncbi.nlm.nih.gov/pubmed/27270429
http://dx.doi.org/10.1038/onc.2016.196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464402/
https://www.ncbi.nlm.nih.gov/pubmed/27270429
http://dx.doi.org/10.1038/onc.2016.196

Ejemplares similares