Identification of key amino acid residues in the hTGR5–nomilin interaction and construction of its binding model

TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases. We previously showed that nomilin, a citrus limonoid, activates TGR5...

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Detalles Bibliográficos
Autores principales: Sasaki, Takashi, Mita, Moeko, Ikari, Naho, Kuboyama, Ayane, Hashimoto, Shuzo, Kaneko, Tatsuya, Ishiguro, Masaji, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464637/
https://www.ncbi.nlm.nih.gov/pubmed/28594916
http://dx.doi.org/10.1371/journal.pone.0179226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464637/
https://www.ncbi.nlm.nih.gov/pubmed/28594916
http://dx.doi.org/10.1371/journal.pone.0179226

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