Construction of an immunotoxin, HN3-mPE24, targeting glypican-3 for liver cancer therapy

Glypican-3 (GPC3) is overexpressed in hepatocellular carcinoma (HCC). We constructed a recombinant immunotoxin, HN3-mPE24, which contains a truncated form of Pseudomonas exotoxin A. The toxin portion lacks most of domain II and has seven point mutations in domain III to remove the B-cell epitopes th...

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Detalles Bibliográficos
Autores principales: Wang, Chunguang, Gao, Wei, Feng, Mingqian, Pastan, Ira, Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464801/
https://www.ncbi.nlm.nih.gov/pubmed/27419635
http://dx.doi.org/10.18632/oncotarget.10592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464801/
https://www.ncbi.nlm.nih.gov/pubmed/27419635
http://dx.doi.org/10.18632/oncotarget.10592

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