NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition

Fatty acid synthase (FAS), as a key enzyme involved in de novo lipogenesis, is highly expressed in many cancers. FAS inhibition induces cell death in vivo and in vitro, rendering FAS as an attractive target for cancer therapy, but the defined mechanism is still not well understood. Herein, we confir...

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Detalles Bibliográficos
Autores principales: Cui, Yanfen, Xing, Pan, Wang, Yuanyuan, Liu, Miao, Qiu, Li, Ying, Guoguang, Li, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464810/
https://www.ncbi.nlm.nih.gov/pubmed/28427229
http://dx.doi.org/10.18632/oncotarget.15936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464810/
https://www.ncbi.nlm.nih.gov/pubmed/28427229
http://dx.doi.org/10.18632/oncotarget.15936

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